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However, implication of LXRs in the selective uptake of cholesterylesters from lipoproteins in human macrophages has never been reported.
2
A simple method has been developed for labelling human plasma lipoproteins to high specific radioactivity with radioactive cholesterylesters in vitro.
3
They serve to transport endogenously synthesized lipids, mainly triglycerides (but also some cholesterol and cholesterylesters) to peripheral tissues.
4
Lysosomal acid lipase (LAL) is a key enzyme that cleaves cholesterylesters and triglycerides to generate free fatty acids and cholesterol in lysosomes.
5
Inhibition of ACAT, the enzyme which catalyses the intracellular formation of cholesterylesters, is a very attractive target for the treatment of hypercholesterolaemia and atherosclerosis.
1
This occurs through the maintenance of caveolae cholesterol content by cholesterolester uptake from HDL.
2
Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterolester between lipoprotein particles.
3
Conclusions: The authors concluded that FEL irradiation can remove cholesterolester selectively from human atheromatous CA plaques.
4
In the absence of active LPL in the same tissue, inactive LPL only mediates selective cholesterolester uptake.
5
We observed abnormal hepatic accumulation of cholesterol in the homozygote individuals, supporting the diagnosis of cholesterolester storage disease.
1
The process begins with a vascular injury that is complicated by the deposition of cholesterolesters and cholesterol.
2
Increases in absolute amounts of EPA and DHA in fasting serum triglycerides, cholesterolesters and phospholipids were examined.
3
On the other hand, an EPA-rich diet produced a marked increase of this fatty acid, especially in cholesterolesters.
4
In contrast, the incorporation of exogenous oleate into secreted triacylglycerols and cholesterolesters was unaffected by deficiency of ABHD5.
5
The cholesterol ester transfer protein (CETP) facilitates the transfer of HDL cholesterolesters from plasma to the liver.
Usage of cholesteryl ester in English
1
The mechanism of cholesterylester accumulation in smooth muscle cells was investigated.
2
When membrane cholesterol levels are low, absorption of cholesterol effectively drives cholesterylester hydrolysis.
3
This difference is consistent with reports of the nonendocytotic selective uptake of HDL-associated cholesterylester.
4
Unexpectedly, cholesterylester transfer protein was not required to determine the human-like cholesterol lipoprotein profile.
5
Our results demonstrate that lysosomal hydrolysis of cholesterylester is independent of the presence of extracellular acceptors.
6
We show that net hydrolysis of cholesterylester is coupled to the transfer of cholesterol to membranes.
7
These results show that aortic smooth muscle cells in cooperation with macrophages can accumulate cholesterylester from beta-VLDL.
8
In endosomes and lysosomes cholesterylester is hydrolyzed by acidic cholesterylester hydrolase producing cholesterol and fatty acids.
9
Here, we have studied endosomal and lysosomal cholesterylester metabolism in cultured mouse macrophages and with cell-free extracts.
10
J774 and elicited mouse peritoneal macrophages were loaded with cholesterylester within lysosomes through phagocytosis of sonicated lipid droplets.
11
Human plasma lipid transfer protein ( cholesterylester transfer protein) has been characterized for its solution and surface properties.
12
The formation of cholesterol monohydrate crystals was observed in cholesterylester-loaded macrophages after a 48-h incubation by polarizing light microscopy.
13
A reduction in cholesterylester transfer protein (CETP) activity has been advanced to explain most lipid-modulating effects of NA.
14
Additional Mendelian randomization analysis failed to clarify the involvement of cholesterylester transfer protein in alcohol-related changes in lipoprotein cholesterol levels.
15
Electron microscopy and acid phosphatase cytochemistry of lysosomes in cholesterylester-loaded cells confirmed that cholesterol crystal formation occurred within lipid-loaded lysosomes.
16
Thus, the present data do not rule out the involvement of direct HDL-cell interaction in the selective uptake of HDL cholesterylester.